Dr. Donald P. EvenSon Ph. D., HCLD

Dr. Donald P. Evenson, Ph.D., HCLD is a Distinguished Professor of Biochemistry at South Dakota State University and President and Director of SCSA® Diagnostics, Inc. a private corporation that is solely dedicated to using the SCSA® test to determine the relationship between infertility and DNA fragmentation in sperm. Dr. Evenson invented and developed the SCSA® test and has over 20 years experience measuring tens of thousands of animal and human sperm samples. Therefore, Dr. Evenson is likely the most knowledgeable and experienced person in the world to conduct, analyze and interpret this complex assay.

Dr. Donald Evenson Dr. Evenson received his B.A. degree in Biology-Chemistry at Augustana College, Sioux Falls, SD and his Ph.D. in Molecular and Cellular Biology at the University of Colorado, Department of Molecular, Cellular and Developmental Biology, Boulder, CO. Following his Ph.D. studies, Dr. Evenson was a postdoctoral fellow at the Institute for Molecular Biophysics, Florida State University, Tallahassee, FL where he studied mammalian chromosome structure.

After studying the structure of viral chromosomes for two years as a staff scientist at the Union Carbide Research Institute in Tarrytown, NY, Dr. Evenson accepted a joint faculty appointment at the Memorial Sloan Kettering Cancer Center and the Cornell Graduate School for Medical Sciences in New York City where for eleven years he used electron microscopy to study the structure of cancer virus and human sperm chromosomes. During the last five years of his tenure in New York, Dr. Evenson was appointed to the Flow Cytometry Laboratory at Memorial Sloan Kettering, which was one of the few laboratories credited with the invention of the flow cytometer in the late 1960's. Dr. Evenson initially used this sophisticated, laser-driven and computer-interfaced instrument in studying the effects of chemotherapy agents on mammalian chromosomes.

Dr. Evenson and his colleagues at Memorial Sloan Kettering invented the Sperm Chromatin Structure Assay (SCSA®) test. Their first paper on the potential power of the SCSA® test for human and animal fertility studies was published in the prestigious journal Science (December 5, 1980) with green (fertile) and red (infertile) acridine orange-stained sperm pictured on the cover. Since the publication of this first study, the SCSA® test has been proven time and again to be one of the most powerful assays used in fertility and toxicology studies. Dr. Evenson was awarded a U.S. Patent for the SCSA® test for infertility assessment.

In 1983, Dr. Evenson moved with his family to live on his grandfather's homestead farm and accepted a position as Professor of Biochemistry at South Dakota State University. During his tenure at SDSU, Dr. Evenson has supervised graduate students, published over a hundred articles in peer reviewed journals, participated in extensive collaborations with international laboratories, been invited to speak around the world on six continents and obtained over 3 million dollars in grant monies.

SCSA® Diagnostics, Inc. continues to participate in a variety of ongoing national and international clinical studies. Data with significance for clinical management will be placed on the website.

HONORS AND RECOGNITIONS:

Distinguished Professor, 1996
Excellence in Research:
Gamma Sigma Delta, 2001
South Dakota Board of Regents, 1997
Sigma Xi, 1995
FO Butler Foundation, 1988
Augustana College Alumni Achievement
Award -- 2005

SCIENTIFIC SOCIETY MEMBERSHIP:

American Society for Reproductive Medicine (ASRM)
European Society for Human Reproduction and Embryology (ESHRE)
Society for the Study of Reproduction (SSR)
American Fertility Society (AFS)
American Society of Andrology (ASA)
American Urology Associates
Resolve - The National Infertility Association
Society for Male Reproduction and Andrology
Alpha
American Association of Bioanalysts
International Society for Analytical Cytology (ISAC)
Genetic Toxicology Society
Environmental Mutagen Society (EMS)
Genotoxicity and Environmental Mutagen Society
Sigma Xi

EXTERNAL SPONSORSHIP (at SDSU ~$3 million):

National Institutes of Health
National Institute of Environmental Health Sciences
Environmental Protection Agency
American Heart Association
National March of Dimes
United States Department of Agriculture
Nordic Countries Academy of Science grant award for international scholars
National Science Foundation
Spinal Cord Research Foundation

PROFESSIONAL AND/OR RESEARCH CONTRIBUTIONS:

Associate Editor, Cytometry Journal
Finance Officer and Committee member, International Society for Analytical Cytology (ISAC), 1994
Steering Committee member, National Science Foundation EPSCoR program for South Dakota

AD HOC REVIEWER OF MANUSCRIPTS:

Human Reproduction
Fertility and Sterility
Human Molecular Reproduction
Journal of Andrology
Biology of Reproduction
Chromosoma
Experimental Cell Research
Journal of Animal Science
Reproductive Toxicology
Theriogenology

AD HOC REVIEWER of RESEARCH GRANTS:

National Institutes of Health
United States Department of Agriculture, Competitive Research Grants
National Science Foundation
Canadian Medical Research Council
National March of Dimes

PUBLICATION and PRESENTATION RECORD

2007 Publications:

•66) Evenson D, Wixon R. (2007) Data analysis of two in vivo fertility studies using SCSA derived DNA Fragmentation Index (DFI) vs pregnancy outcome. Fertility and Sterility in press

•65) Werthman P, Wixon R, Kasperson K, Evenson D. (2007) Significant decrease in sperm deoxyribonucleic acid fragmentation after varicocelectomy. Fertility and Sterility in press

2006 Publications:

64)Evenson, DP (2006) Reply to: ‘The predictive value of the sperm chromatin structure assay (SCSA®)’—a response from the SCSA inventor, Human Reproduction 21(2):570-572.

2005 Publications:

63)Rubes, J., Selevan, S. G., Sram, R. J., Evenson, D. P. And Perreault, S. D. (2005) Impact of Air Pollution of Reproductive Health in Northern Bohemia. Environment and Fertility. Editors: P. Nicolopoulou-Stamati, L. Hens, CV Howard. Springer: in press.
62)Evenson, D. P. and Wixon, R L. (2005) Comparison of the Halosperm test kit with the SCSA infertility test in relation to patient diagnosis and prognosis. Fertil Steril. Oct;84(4):846-9.
61)Evenson, D. P. and Wixon, R L. (2005) Clinical aspects of sperm DNA fragmentation detection and male infertility. Theriogenology. Oct 17;
60)Evenson, D. P. and Wixon, R L. (2005) Environmental toxicants cause sperm DNA fragmentation as detected by the Sperm Chromatin Structure Assay (SCSA®). Toxicol Appl Pharmacol. Sep 1;207(2 Suppl):532-7.
59)Rubes, J., Selevan, S. G., Evenson, D. P., Zudova, D., Vozdova, M., Zudova, Z., Robbins, W. A., Perreault, S. D., (2005) Episodic Air Pollution is Associated with Increased DNA Fragmentation in Human Sperm without other Changes in Semen Quality. Hum Reprod. 2005 Oct;20(10):2776-83. Epub 2005 Jun 24.
58)Silver EW, Eskenazi B, Evenson DP, Block G, Young S, Wyrobek AJ. Effect of antioxidant intake on sperm chromatin stability in healthy nonsmoking men. J Androl. Jul-Aug;26(4):550-6.

2004 Publications:

57)Brake, D.G. and Evenson, D.P. (2004) A generational study of glyphosphate-tolerant soybeans on mouse fetal, postnatal, pubertal and adult testicular development. Food Chem Tox 42:29-36.
56)Virro, M.R., Larson-Cook, K.L. and Evenson,D.P. (2004) Sperm chromatin structure assay (SCSA®) related to blastocyst rate, pregnancy rate and spontaneous abortion in IVF and ICSI cycles. Fertility and Sterility 81:1289-1295.
55)Brake, D.G. and Evenson, D.P. (2004) No negative effects of transgenic Bt corn male mouse reproductive development. J Agric Food Chem 7:2097-102.
54)Doeringsfeld, M.R., Schlosser, I.J., Elder, J.F. and Evenson, D.P. (2004) Phenotypic consequences of genetic variation in a gynogenetic complex of Phoxinus eos-neogaeus clonal fish (Pisces: Cyprinidae) inhabiting a heterogeneous environment. Evolution Int J Org Evolution.Jun;58(6):1261-73.
53)Alvarez, J.G., Larson-Cook, K.L., Evenson, D.P. (2004) Selecting cryopreserved semen for assisted reproductive techniques (ART) based on the level of sperm nuclear DNA fragmentation resulted in pregnancy. Fertility and Sterility 81:712-713

2003 Publications:

52)Larson-Cook, K., Brannian, J.D., Hansen, K.A., Kasperson, K., Aamold, E.T., and Evenson, D.P. (2003) Relationship between the outcomes of assisted reproductive techniques and sperm DNA fragmentation as measured by the sperm chromatin structure assay. Fertil Steril 80:4;895-902.
51)Penfold, L.M., Jost, L., Evenson, D.P., and Wildt, D.E. (2003) Normospermic versus teratospermic domestic cat chromatin integrity evaluated by flow cytometry and intracytoplasmic sperm injection. Biol of Reprod 69: 1730-1735.
50)Evenson, D.P., and DeJonge, C. (2003) Uniqueness and predictive power of the sperm chromatin structure assay (SCSA) in the infertility clinic. ESHRE.
2002 Publications and Submissions:
49)Alvarez, J.G., Sharma, R.K., Ollero, M., Saleh, R.A., Lopez, M.C., Thomas, A.J., Jr., Evenson, D., and Agarwal, A. (2002) Increased DNA damage in sperm from leukocytospermic semen samples as determined by the sperm chromatin structure assay (SCSA). Fertil Steril 78: 319-329.
48)Saleh R.A., Agarwal A., Kandirali E., Sharma R.K., Thomas A.J. Jr., Nada E.A., Evenson D.P., and Alvarez J.G. (2002): Leukocytospermia is associated with increased reactive oxygen species production by human sperm. Fertil Steril 78:1215-1224.
47)Evenson, D.P. and Spano, M. (2002) Flow Cytometry analysis of mammalian sperm. Proceedings of the 9th International Symposium on Spermatology, Oct 6-12, Capetown, South Africa.
46)Evenson, D.P. (2002) Assessment of sperm using the sperm chromatin structure assay. Proceedings UCLA 15th Annual In Vitro Insemination and Embryo Transfer Course, July 14-17, UCLA, 2002.
45)Evenson, D.P. (2002) Role of sperm chromatin damage in abnormal reproductive outcomes. Society for Theriogeneology /ACT Annual Conference & Symposia Proceedings. Published by SFT. Colorado Springs, CO, Aug 7-11, 2002.
44)Sakkas, D., and Evenson D.P. (2002) Assessment of sperm nuclear DNA integrity. Alpha - Scientists in Reproductive Medicine. April 25, (25) 1-3.
43)Evenson, D.P., Larson, K., and Jost, L.K. (2002) The sperm chromatin structure assay (SCSATM): clinical use for detecting sperm DNA fragmentation related to male infertility and comparisons with other techniques. Andrology Lab Corner. J. Andrology 23: 25-43.
42)Selevan, S.G., Borkovec, L., Slott, V.L., Zudova, A., Rubes, J., Evenson, D.P., and Perreault, S.D. (2002)Semen quality and reproductive health of young Czech men exposed to seasonal air pollution. Environ Health Perspect. 108:887-894.
41)Perreault, S.D., Aitken R.J., Baker, H.W.G., Evenson, D.P., Huszar, G., Irvine D.S., Morris, R.A., Robbins W.A., Sakkas D., Spano, M., and Wyrobek, A.J. (2003) Integrating new tests of sperm genetic integrity into semen analysis: summary of breakout group discussion. In: B. Robaire and B.F. Hales (eds.) Advances in Male Mediated Developmental Toxicology. Kluwer Press, New York. 253-268.

Selected Peer - Reviewed Publications:

40)Ollero M, Gil-Guzman E, Lopez MC, Sharma RK, Agarwal A, Larson KL, Evenson DP, Thomas AJ Jr, Alvarez JG. 2001. Characterization of subsets of human sperm at different stages of maturation: implications in the diagnosis and treatment of male infertility. Human Reprod, 16:1912-1921.
39)Larson KL, Brannian JD, Singh NP, Burbach JA, Jost LK, Hansen KP, Kreger DO, Evenson DP. 2001. Chromatin structure in globozoospermia: a case report. J Androl 22: 424-431.
38)Evenson D. 2001. Utility of the sperm chromatin structure assay in the ART laboratory. Reprod Medicine Forum 1: 8-10.
37)Kobayahsi H, Larson K, Sharma RK, Nelson DR, Evenson DP, Toma H, Thomas AJ, Agarwal A. 2001. DNA damage in patients with untreated cancer as measured by the sperm chromatin structure assay. Fertil Steril 75:469-475.
36)Evenson DP, Jost LK, Perreault SD, Selevan SG, Rubes J. 2001. Application of the sperm chromatin structure assay to the Teplice Program semen studies: a new method for evaluating sperm nuclear chromatin damage. Proceedings of Conference on the Teplice Program, Academia, pp 167-180.
35)Krzyzosiak J, Evenson D, Pitt C, Jost L, Molan P, Vishwanath R. 2000. Changes in susceptibility of bovine sperm to in situ DNA denaturation during prolonged storage at ambient temperature under conditions of exposure to reactive oxygen species and nuclease inhibitor. Reprod, Fert & Devel. 12: 251-261.
34)Evenson DP, Jost LK, Corzett M, Balhorn R. 2000. Characteristics of human sperm chromatin structure following an episode of influenza and high fever: a case study. J Androl 21: 739-746.
33)Larson K, DeJonge C, Barnes A, Jost L, Evenson D. 2000. Sperm Chromatin Structure Assay parameters as predictors of failed pregnancy following assisted reproductive techniques. Human Reprod 15: 1717-1722.
32)Evenson DP. 1999. Loss of livestock breeding efficiency due to uncompensable sperm nuclear defects. Reprod, Fert & Devel. 11:1-15.
31)Lemasters GK, Olsen DM, Yiin JH, Lockey JE, Shukla R, Selevan SG, Schrader SM, Toth GP, Evenson DP, Huszar GB. 1999. Male reproductive effects of solvent and fuel exposure during aircraft maintenance. Reprod Tox 13:155-166.
30)Evenson DP. 1999. Alterations and damage of sperm chromatin structure and early embryonic failure. In: Towards Reproductive Certainty: Fertility and Genetics Beyond 1999. (Jannsen R, Mortimer D, eds). Plenary Proceedings of the 11th World Congress on In Vitro Fertilization and Human Reproductive Genetics. Parthenon Publishing Group Ltd., New York/London. Chapter 15, pp 313-329.
29)Evenson DP, Jost LK, Zinaman MJ, Clegg E, Purvis K, de Angelis P, Clausen OP. 1999. Utility of the Sperm Chromatin Structure Assay (SCSA) as a diagnostic and prognostic tool in the human fertility clinic. Human Reprod 14:1039-1049.
28)Ellington JE, Evenson DP, Fleming J, Rice G, Brisbois S, Hiss G, Wright R, Benson A, Broder S. 1998. Coculture of human sperm with bovine oviduct epithelial cells decreases sperm chromatin structural changes during culture in medium alone. Fertil Steril 69:643-649.
27)Aravindan GR, Bjordahl J, Jost LK, Evenson DP. 1997. Susceptibility of human sperm to in situ DNA denaturation is strongly correlated with DNA strand breaks indentified by single-cell electrophoresis. Exp Cell Res 236:231-237.
26)Fossa SD, De Angelis P, Kraggerud SM, Evenson D, Theodorsen L, Claussen OP. 1997. Prediction of post-treatment spermatogenesis in patients with testicular cancer by flow cytometric sperm chromatin structure assay. Comm in Clinical Cytometry 30:192-196.
25)Karabinus DS, Vogler CJ, Saacke RG, Evenson DP. 1997. Chromatin structural changes in bovine sperm after scrotal insulation of Holstein bulls. J Androl 18:549-555.
24)Sailer BL, Sarkar LJ, Jost LK, Bjordahl J, Evenson DP. 1997. Effects of heat stress on mouse testicular cells and sperm chromatin structure as measured by flow cytometry. J Androl 18:294-301.
23)Evenson DP. 1997. Sperm nuclear DNA strand breaks and altered chromatin structure: Are there concerns for natural fertility and assisted fertility in the andrology lab? Moving Beyond Boundaries: Clinical Andrology in the 21st Century. Andrology Laboratory Workshop. Postgraduate Course. Baltimore, MD.
22)Evenson DP, Sailer BL, Jost LK. 1995. Relationship between stallion sperm deoxyribonucleic acid (DNA) susceptibility to denaturation in situ and presence of DNA strand breaks: Implications for fertility and embryo viability. Biol Reprod Monog 1: Equine Reproduction VI, pp. 655-659.
21)Sailer BL, Jost LK, Evenson DP. 1995. Mammalian sperm DNA susceptibility to in situ denaturation associated with the presence of DNA strand breaks as measured by the Terminal Deoxynucleotidyl Transferase Assay. J Androl 16:80-87.
20)Sailer BL, Jost LK, Erickson KR, Tajiran MA, Evenson DP. 1995. Effects of X-ray irradiation on mouse testicular cells and sperm chromatin structure. Environ and Mol Mutagen 25:23-30.
19)Evenson DP, Thompson L, Jost L. 1994. Flow cytometric evaluation of boar semen by the sperm chromatin structure assay as related to cryopreservation and fertility. Therio 41:637-651.
18)Estop AM, Munne S, Jost LK, Evenson DP. 1993. Alterations in sperm chromatin structure correlates with cytogenetic damage of mouse sperm following in vitro incubation. J Androl 14:282-288.
17)Evenson DP, Emerick RJ, Jost LK, Kayongo-Male H, Stewart SR. 1993. Zinc-Silicon interactions influencing sperm chromatin integrity and testicular cell development in the rat as measured by flow cytometry. J Anim Sci 71:955-962.
16)Evenson DP, Thompson L. 1991. Flow cytometric analysis of boar sperm chromatin structure as related to cryopreservation and fertility. In: Proc of Second International Conference on Boar Semen Preservation (Johnson LA, Rath D, eds) pp 165-183.
15)Evenson DP, Jost L, Baer R, Turner T, Schrader S. 1991. Individuality of DNA denaturation patterns in human sperm as measured by the sperm chromatin structure assay. Reprod Tox 5:115-125.
14)Evenson DP, Baer RK, Jost LK. 1989. Flow cytometric analysis of rodent epididymal spermatozoal chromatin condensation and loss of free sulfhydryl groups. Mol Reprod & Devel 1:283-288.
13)Evenson DP, Baer RK, Jost LK. 1989. Long term effects of triethylenemelamine exposure on mouse testis cells and sperm chromatin structure assayed by flow cytometry. Environ & Mol Mutagen 14:79-89.
12)Evenson DP. 1989. Flow cytometric analysis of toxic chemical induced alterations in testicular cell kinetics and sperm chromatin structure. In: New Trends in Genetic Risk Assessment (Jolles G, Cordier A, eds). Academic Press, NY, pp 343-365.
11)Evenson DP. 1989. Flow cytometry evaluation of male germ cells. In: Flow Cytometry: Advanced Research and Clinical Applications, Vol I. (Yen A, ed). CRC Press, Boca Raton, FL. pp 217-246.
10)Ballachey BE, Saacke RG, Evenson DP. 1988. The sperm chromatin structure assay: Relationship with alternate tests of sperm quality and heterospermic performance of bulls. J Androl 9:l09-115.
9)Ballachey BE, Hohenboken WD, Evenson DP. 1987. Heterogeneity of sperm nuclear chromatin structure and its relationship to fertility of bulls. Biol Reprod 36:915-925.
8)Evenson DP. 1986. Male germ cell analysis by flow cytometry: Effects of cancer, chemotherapy and other factors on testicular function and sperm chromatin structure. In: Clinical Cytometry (Andreeff, M.A., ed). NY Academy of Science, pp 350-367.
7)Evenson DP. 1986. Flow cytometry of acridine orange stained sperm is a rapid and practical method for monitoring occupational exposure to genotoxicants. In: Monitoring of Occupational Genotoxicants (Sorsa M, Norppa H, eds). Alan Liss, NY. pp 121-132.
6)Evenson DP, Klein FA, Whitmore WF, Melamed MR. 1984. Flow cytometric evaluation of sperm from patients with testicular carcinoma. J Urology 132:1220-1225.
5)Evenson DP, Darzynkiewicz Z, Melamed MR.1981. Flow cytometric analysis of sperm chromatin structure. Acta Pathol. Microbiol. Scand. 274:191-195.
4)Evenson DP, Darzynkiewicz Z, Melamed MR. 1980. Relation of mammalian sperm chromatin heterogeneity to fertility. Science 240:1131-1133.
3)Evenson DP, Darzynkiewicz Z, Melamed MR. 1980. Comparison of human and mouse sperm chromatin structure by flow cytometry. Chromosoma 78:225-238.
2)Evenson DP, Witkin S, deHarven E, Bendich A. 1978. Ultrastructure of partially decondensed human spermatozoal chromatin. J. Ultrastruc. Res. 63:178-187.
1)Evenson DP, Mego WA, Taylor JH. 1972. Subunits of chromosomal DNA. I. Electron microscopic analysis of partially denatured DNA. Chromosoma 30:225-235.

2008 Abstracts:

• Didion B, Wixon R, Evenson D. (2008) Boar fertility and sperm chromatin structure status: a retrospective report. ASA 2008

2007 Abstracts:

•Evenson Donald P, Wixon Regina, (2007) Recurrent Pregnancy Loss. Fertility Magazine 6: 38-39.

•Evenson Donald P, Wixon Regina, Kasperson Kay, Werthman Philip, (2007) Poster Presentaton. SIGNIFICANT DECREASE IN SPERM DEOXYRIBONUCLEIC ACID FRAGMENTATION AFTER VARICOCELECTOMY. ASA

•Evenson Donald P, Wixon Regina (2007) Oral Presentation. Updates on sperm DNA fragmentation data and clinical suggestions. AAB

2006 Abstracts:

Evenson, D.P. and Wixon, R. (2006) Poster : International Consensus from Multiple Laboratories on the SCSA Threshold for Men at Risk for Infertility American Society of Andrology, April 8-11th, Chicago, Illinois.

2005 Abstracts:

Evenson DP, Wixon RL. (2005) Abstract, Meta-analysis of SCSA® defined DFI and PG outcomes. ESHRE
Wixon RL, Evenson DP, (2005) Abstract, Correlations between SCSA®- defined DFI scores and pregnancy outcomes are dependent on mode of fertilization. 6th Dakota Reproductive Biology Symposium
C St Dennis, J Schimmels, R Short, GD Clifton, D Grubb, D Evenson, & J Ellington, (2005) Abstract, Selective Serotonin Reuptake Inhibitor (SSRI) causes sperm chromatin damage in smoking men, ASA
Evenson DP, Wixon RL, (2005) Abstract, Meta-analysis of SCSA® defined DFI and PG outcomes. ASRM Montreal Canada.
D. Evenson and R. Wixon, (2005) Abstract, USE OF THE SPERM CHROMATIN STRUCTURE ASSAY (SCSA® ) AS A DIAGNOSTIC TOOL IN THE HUMAN INFERTILITY CLINIC 3rd International Congress on Male-Mediated Developmental Toxicity Bradford, UK July 31 thru August 3
D. Evenson and R. Wixon, (2005) Abstract, USE OF THE SCSA FOR DETECTION OF ALTERED SPERMATOGENESIS AND FRAGMENTED SPERM DNA FOR TOXICOLOGY AND INFERTILITY STUDIES. UK Environmental Mutagen Society Bradford UK August 3/5, 2005
Evenson DP, Wixon RL. (2005) Abstract, PREDICTIVE ABLILITY OF THE SCSA® USING ODDS RATIO, IVF Istanbul May 26/29.
Evenson DP, Wixon RL, (2005) Abstract, SPERM DNA FRAGMENTATION AND PREGNANCY OUTCOME, IETS
Evenson DP, Wixon RL, (2005) Reply to: The Predictive Value of the Sperm Chromatin Structure Assay (SCSA®) - A Response from the SCSA Inventor, Human Reproduction, in press
Evenson DP, Wixon RL, (2005) Article, Sperm DNA Damage Contributes to Failed Pregnancy Fertility Today
Evenson DP, Wixon RL. (2005) Article, USE OF THE SPERM CHROMATIN STRUCTURE ASSAY (SCSA®) AS A DIAGNOSTIC TOOL IN THE HUMAN INFERTILITY CLINIC Fertility World
Evenson DP, Wixon RL, (2005) Article, The Aging Male and Infertility Infertility Awareness Association of Canada
Evenson, DP, (2005) Article, Sperm DNA fragmentation: The role of the urologist/male infertility specialist. BUSINESS BRIEFS: US Kidney and Urological Disease.
Evenson DP, Wixon RL, (2005) Letter to the Editor, Sperm Chromatin Structure Assay (SCSA) defined Fertility Sterility in press
Evenson DP, Wixon RL, (2005) Article, “The Silver Anniversary of the Gold Standard of Sperm DNA Fragmentation” Infertility Times (March) Vol 3, No 1, pp 4/5.
Evenson DP, Wixon RL, (2005) Article, The Trauma of Infertility RESOLVE of Houston’s FAMILY Resolutions. Spring,

2004 Abstracts:

Evenson, D.P. and Tritle, D. (2004)Poster: The SCSA is a direct measure of sperm DNA. Annual Meeting of the American Society for Reproductive Medicine. Pennsylvania Convention Center, Philadelphia, Pennsylvania, October 16-20.
Wyrobek, A.J., Eskenazi, B.E., Young, S., Hill, F., Evenson, D., Arnheim, N. (2004) Advancing age among healthy males is associated with increased frequencies of sperm with DNA fragmentation and ACH gene mutations, but not aneuploidies or diploidies. American Society of Human Genetics. Toronto Ontario,October 26-30
Evenson, D.P. (2004) Poster: Clinical importance of sperm DNA fragmentation measurement at diagnosis of cancer in young men and following recovery at time of fertilization attempts. Parenthood after Cancer: Today's Options and Tomorrow's Hopes Conference. Sponsored by MD Anderson Cancer Center and the Lance Armstrong Foundation, March 5-7.
Evenson, D.P. and Tritle, D. (2004)Platform Presentation: Characterization of SCSA Resolved Sperm Populations by Comet Assay and Image Analysis. IFFS 8th World Congress on Fertility and Sterility, Palais des congres de Montreal, Montreal, Quebec Canada, May 23-28.
Evenson, D.P. (2004) Invited Speaker. Is Sophisticated Sperm Analysis Ever Required? The Fifth World Congress on Controversies in Obstetrics, Gynecology & Infertility, Paris Hotel, Las Vegas, NV, June 3-6.
Rubes, J., Selevan, S., Evenson, D.P., Zudova, D., Vozdova, M., Zudova, Z., Robbins, W., Perreault, S.D. (2004) Poster: GST M1 Genotype Influences Sperm DNA Damage with Exposure to Air Pollution. Society for Epidemiologic Research, Salt Lake City, UT, June 15-18th.
Evenson, D.P. and Tritle, D. (2004) The SCSA® is a direct measure of sperm DNA fragmentation. European Society of Human Reproduction and Embryology International Congress Centre Berlin, Berlin, Germany, June 27-30.
Evenson, D.P. (2004) Invited Speaker. Environmental toxicants cause sperm DNA fragmentation as detected by the Sperm Chromatin Structure Assay (SCSA). The 10th International Congress of Toxicology, Tampere, Finland, July 11-15.

2003 Abstracts:

Virro, M.R., Larson-Cook, K.L., Evenson, D.P. (2003) Platfrom Presentation. Sperm chromatin structure assay (SCSA®) parameters relationship with fertilization rate, blastocyst development and pregnancy outcomes following in vitro fertilization (IVF) and IVF with intracytoplasmic sperm injection (ICSI). American Society for Reproductive Medicine. San Antonio, TX, Oct. 11-15.
Larson-Cook, K.L., Brannian, J.D., Hansen, K.A., Bormann, S.F. Evenson, D.P. Sperm chromatin structure assay (SCSA) parameters provide additional prognostic information to conventional semen analysis for couples trying to conceive. American Society for Reproductive Medicine. San Antonio, TX. Oct. 11-15.
Morris, R.A., Jeffay, S.C., Strader, L.F., Evenson, D.P., Olshan, A.F., Lansdell, L.W., Perreault, S.D. "Evaluation of Sperm Chromatin Structure Assay (SCSA®) DNA Fragmentation Index (DFI) Levels in Human Sperm after Simulated Overnight Shipment." American Society of Andrology. Phoenix, AZ. March 26-29.
Virro, M.R., Larson-Cook, K.L., Evenson, D.P. (2003) Sperm chromatin structure assay (SCSA®) related to blastocyst rate, pregnancy rate and spontaneous abortion in IVF and ICSI cycles. Pacific Coast Reproductive Society 2003 Annual Meeting. Rancho Mirage, CA. April 23 - 27.

2002 Abstracts

Larson-Cook, K., Brannian, J., Hansen, K., Jost, L. and Evenson, D. (2002) Relationship between assisted reproductive techniques (ART) outcomes and DNA fragmentation (DFI) as measured by the Sperm Chromatin Structure Assay (SCSA). American Society for Reproductive Medicine. Seattle, WA, Oct 12-17. #100777.
Virro, M., Evenson, D. (2002) The SCSA as a predictor of failed IVF and ICSI initiated pregnancies. 11th World Congress on Human Production, Montreal, Ontario.
Saleh, R.A., Agarwal, A., Thomas, A.J., Jr., Sharma, R.R., Nelson, D.R., Larson, K.L., Evenson, D.P. (2002) Increased levels of sperm chromatin structure assay-defined DNA damage in infertile men with varicocele. American Urology Association Meeting. Orlando.
Evenson, D., Wyrobek, A., Eskanezi, B., Young, S. (2002) Loss of sperm DNA integrity with donor age. American Urology Association national meeting. Orlando.
Rubes, J., Selevan, S.G., Zudova, D., Evenson, D.P., and Perreault, S.D. (2002) Longitudinal study of semen quality after intermittent exposure to air pollution. International Society for Environmental Epidemiology.
Perreault, S.D., Selevan, S.G., Evenson, D.P., and Rubes, J. (2002) Air pollution effects on semen quality. HEI Annual Conference. Washington, D.C., April 29- May 1.
Evenson, D.P., Steiner, J.V., and Jost, L.K. (2002) Diagnostic and prognostic value of the sperm chromatin structure assay for stallion sub/infertility. Eighth International Symposium on Equine Reproduction. Fort Collins, CO. July 21-26.

Selected 2008 Presentations:

•Didion B, Wixon R, Evenson D. (2008) Boar fertility and sperm chromatin structure status: a retrospective report. ASA 2008

Selected 2007 Presentations:

•Evenson Donald P, Wixon Regina, Kasperson Kay, Werthman Philip, (2007) Poster Presentaton. SIGNIFICANT DECREASE IN SPERM DEOXYRIBONUCLEIC ACID FRAGMENTATION AFTER VARICOCELECTOMY. ASA 2007

•Evenson Donald P, Wixon Regina (2007) Oral Presentation. Updates on sperm DNA fragmentation data and clinical suggestions. AAB

Selected 2006 Presentations:

Evenson, D.P. and Wixon, R. (2006) Poster Presentation: International Consensus from Multiple Laboratories on the SCSA Threshold for Men at Risk for Infertility American Society of Andrology, April 8-11th, Chicago, Illinois.

Selected 2005 Presentations:

Evenson, D.P. (2005) Invited speaker: “Sperm DNA Fragmentation As Related to Male Infertility” presented at Mini-tubes of America, Madison, WI, March 7/8.
Evenson, D.P. (2005) Invited speaker: II International ART Congress, Moscow Russia. April 12/16.
Evenson, D.P. (2005) Attended and Poster Presentation: PREDICTIVE ABLILITY OF THE SCSA® USING ODDS RATIO 13th World Congress on In Vitro Fertilization Assisted Reproduction and Genetics, Istanbul, Turkey. May 26/29.
Evenson, D.P. and Wixon, R. (2005) Poster Presentation and Book Chapter: “DNA fragmentation and pregnancy outcome”, IETS, Copenhagen, Denmark, January 8/12.
Evenson, D.P. and Wixon, R. (2005) Poster Presentation: “Etiology of sperm DNA fragmentation”, Copenhagen Workshop on Environment, Reproductive Health and Fertility, Copenhagen Denmark, January 15/18.

Selected 2004 Presentations:

Platform Speaker for University of Minnesota Department of Chemistry; topic “Biochemistry By Flow Cytometry”. February 12, 2004.
Platform Speaker for University of Texas M. B. Anderson Cancer Center’s Conference on Parenthood After Cancer. March 5-7, 2004.
Platform Speaker at American Society of Andrology Annual Meeting, Baltimore, MD. April 5-17, 2004.
Invited Speaker, “Sperm DNA Fragmentation in Male Infertility” at Northwest Fertility Group of Seattle WA. May 6, 2004.
Platform Speaker at IFFS 18th World Congress on Fertility and Sterility, Montreal, QE Canada. May 23-28, 2004.
Platform Speaker at the 5th World Congress on Controversies in Obstetrics, Gynecology & Infertility at Las Vegas, NV. June 3-6, 2004.
Platform Speaker, “Characterization of SCSA Resolved Sperm Populations by Comet Assay and Image Analysis” at the 20th Annual Meeting of the European Society of Human Reproduction & Embryology at Berlin, Germany. June 27-30, 2004.
Platform Speaker, “Sperm DNA Fragmentation in Male Infertility”, at the 10th International Congress of Toxicology at Tampere, Finland. July 11-5, 2004.
Platform Speaker at the American Society of Reproductive Medicine annual meeting at Philadelphia, PA. October 16-20, 2004.
Invited Speaker at the RESOLVE of Ohio annual meeting at Cleveland, OH.
Invited Speaker at Miami Physicians Group annual meeting at Miami, FL.
November 9, 2004.
Invited Speaker, “Sperm DNA Fragmentation and Pregnancy Outcome”, sponsored by London UK Doctors’ Lab. November 29, 2004.

Selected 2003 Presentations:

Invited guest lecturer. French Reproductive Society, November, Lyon, France.
Invited guest lecturer. Northern California Reproductive Society Meeting. November, San Francisco, CA.
Invited speaker for "DNA Integrity Testing and Infertility Workshop." American Society of Reproductive Medicine Annual Meeting. October, San Antonio, TX.
Guest Lecturer. "The IVF Lab: A Look behind the Scenes" and "Advanced Issues in Sperm Analysis. "Northern California Chapter of Resolve Annual Symposium. September, Oakland, California.
Invited Speaker. "Environmental Toxicants and Male Infertility." Meeting of San Francisco Area Reproductive Endocrinologists. June, San Francisco, CA.
Invited Speaker. Universities in Mexico City. Sponsored by the Mexican Academy of Science. March, Mexico City, Mexico.

Selected 2002 Presentations:

Grand Rounds, Sioux Valley Hospital, OB/GYN Department. "The Sperm Chromatin Stucture Assay as a predictor of subfertility" March, Sioux Falls, SD.
Poster Presentation for the American Society of Andrology; topic "Relationship between age of man, sperm DNA fragmentation and infertility" April, Seattle, WA.
Workshop speaker in session on "The Andrology Laboratory of the Future"; American Society of Andrology; "Automated instrumentation and the dectection of sperm DNA integrity for diagnosis and prognosis of male infertility." (10 pages of Handbook) April, Seattle, WA.
Program speaker in session on Impact of Gamete & Embryo Quality on IVF Outcome; AAB Annual Meeting; "The Sperm Chromatin Structure Assay (SCSA), the Most Practical and Statistically Robust Measure of Sperm DNA Fragmentation for Diagnosis and Prognosis of Male Factor Infertility." April, Myrtle Beach, SC.
Platform Speaker at American Urology Association meetings; "Loss of sperm DNA integrity with donor age" May 25-29, Orlando, FL.
Poster Presentation for the AUA meeting; topic "Increased levels of sperm chromatin structure assay-defined DNA damage in infertile men with varicocele" May 25-29, Orlando, FL.
Platform presentation for The World Congress on Human Reproduction; topic "The SCSA as a predictor of failed IVF and ICSI initiated pregnancies" June 1- 5, Montreal, Canada.
Symposium Speaker for 15th Annual In Vitro Fertilization and Embryo Transfer CME course; "Assessment of Sperm Using the Sperm Chromatin Structure Assay." July 14-17, Santa Barbara, CA.
Invited speaker "Sperm DNA fragmentation as related to male idiopathic infertility" Sept 28, Fairfax, VA.
Symposium Speaker for Annual Conference of the Society for Theriogenology and Symposia, "Use of the SCSA for detecting subfertile animals." August 7-11, Colorado Springs, CO.

Selected 2001 Presentations:

Poster Presentation: "Role of the Sperm Chromatin Structure Assay (SCSA) in the human infertility clinic." International Society of Andrology, June 15-23, Montreal, Canada.
Poster presentation: "Which idiopathic sub/infertility patients should be advised to have a semen test by the Sperm Chromatin Structure Assay (SCSA)?" Third Biennial Alpha Conference, Alpha 2001, Institute for Reproductive Medicine and Science of Saint Barnabas, September 7-12, NY, NY.
Poster presentation: "Utility of the Sperm Chromatin Structure Assay (SCSA) in the Infertility Clinic. Canadian Fertility and Andrology Society, October 1 " 8, Whistler, British Columbia, Canada.
Symposium speaker and workshop leader: "Utility of the Sperm Chromatin Structure Assay (SCSA) in the ART laboratory." American Society of Reproductive Medicine, October 20-25, Orlando, FL.

Selected 2000 Presentations:

Three poster presentations: 25th Annual Meeting American Society of Andrology, April 7-11, Boston, Massachusetts.
Invited Plenary lecturer: "Sperm DNA quality as related to fertility and early embryo development." International Congress on Reproductive Medicine, Obstetrics and Gynecology: Challenges in the 3rd Millenium, April 11-14, Tel Aviv, Israel.
Poster presentation: "Sperm chromatin structure assay: utility for human/animal fertility clinics." XXI Congress of the International Society for Analytical Cytology (ISAC), May 20-25, Montpelier, France.
Invited Speaker: "Uncompensable sperm nuclear defects negatively affect livestock breeding efficiency." International Congress on Animal Reproduction (ICAR), July 2-6, Stockholm, Sweden.
Presentation: "Is a sperm unique apoptotic mechanism responsible for numerous DNA strand breaks existing in mature human sperm?" European Society of Reproduction and Embryology (ESHRE).

Selected 1999 Presentations:

Invited symposium speaker: "Sperm chromatin damage and embryo lethality." International Society of Andrology; Andrology in the 90's, March 25-27, Capetown, South Africa.
Invited seminar speaker: "Assessment of sperm chromatin structure to enhance livestock breeding efficiency." Livestock Improvement Corporation, April, Hamilton, New Zealand.
Invited Plenary lecturer: "Sperm Chromatin Damage and Early Embryonic Failure." 11th World Congress on In Vitro Fertilization and Human Reproductive Genetics. Session on Male Reproductive Health, May 9-14, Sydney, Australia.
Invited speaker: "Sperm chromatin structure and its relationship to fertility." Samuel A. Latt Conference for the International Society for Analytical Cytology (ISAC), July 18-21, Hamilton Island, Queensland, Australia.