Varicocele is found in 19 to 41% of infertile men and considered as the most common cause of male infertility. The exact mechanism(s) by which varicocele affects male fertility is still unknown. Recent data indicate a strong negative impact of increased DNA damage on the fertility potential of men.

Zini showed decreases in %DFI after varicocele repair. Hum Reprod. 2005. 20:1018-21