Toxicology
SCSA Animal Data
Stallions
The SCSA is recognized as an analysis for breeding soundness in the Manual of Equine Reproduction (Mosby 2nd Edition Blanchard TL, Love CC, Varner DD Brinsko SP, Schumaker J, Rigby SL) . The SCSA quickly identifies stallions whose sperm have damaged DNA, thereby reducing the pregnancy rate per cycle/season. While the DFI values are significantly correlated to pregnancy outcome the values are not as high as with bulls. A possible reason is the complexity of the breeding patterns on different farms etc.
Evenson, D.P., Sailer, B.L. and Jost, L.K. (1995) Relationship between stallion sperm deoxyribonucleic acid (DNA) susceptibility to denaturation in situ and presence of DNA strand breaks: Implications for fertility and embryo viability. Biol Reprod Monog 1: Equine Reproduction VI, pp. 655-659.
Kenney, R.M., Evenson, D.P., Garcia, M.C. and Love, C.C. (1995) Relationships between sperm chromatin structure, motility and morphology of ejaculated sperm, and seasonal pregnancy rate. Biol Reprod Monog 1: Equine Reproduction VI, pp. 647-653.
Evenson, D.P., Jost, L.K., and Varner, D.D. (2000) Stallion sperm nuclear protamine -SH status and susceptibility to DNA denaturation are not strongly correlated. J. Reproduction and Fertility Supplement 56: 401-406.
Evenson, D.P., Jost, L.K., and Varner, D.D. (2000) Stallion sperm nuclear protamine -SH status and susceptibility to DNA denaturation are not strongly correlated. J. Reproduction and Fertility Supplement 56: 401-406.
Stallion sample -- excellent sperm DNA integrity
Stallion sample – poor sperm DNA integrity
